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First-generation antihistamines have a significant amount of anticholinergic side effects.
These side effects may include drowsiness, dry mouth, urinary retention (especially in men with prostate enlargement) and constipation.
Antihistamines have been available for more than 50 years, and include older, first-generation versions, such as Benadryl (diphenhydramine), Atarax (hydroxyzine), Periactin (cyproheptadine) and Silenor (doxepin).
These medications have significant side effects and therefore led to the development of second-generation antihistamines, which include Claritin (loratadine), Zyrtec (cetirizine), and Allegra (fexofenadine), which have fewer side effects.
In addition to sedation and dry mouth, antihistamines may have the side effect of increasing appetite and weight gain.
To further examine the sedative effects of four commonly prescribed antihistamines—loratadine, cetirizine, fexofenadine, and acrivastine—we analysed the results of four non-interventional observational cohort studies of these drugs performed by the Drug Safety Research Unit.Anyone have any input about which SSRIs are most or least sedating? I have some friends who take it, and they've said that it's sedating at first, but in some cases it wears off and in others it's fine if taken at bedtime.Side effects: Nausea, insomnia, headaches, sexual dysfunction, jitteriness; possibly drowsiness, dry mouth, constipation.It’s the worst one for weight gain, and among the worst for withdrawal symptoms (unless properly managed).Main outcome measure: Reporting of sedation or drowsiness.Results: The odds ratios (adjusted for age and sex) for the incidence of sedation were 0.63 (95% confidence interval 0.36 to 1.11; P=0.1) for fexofenadine; 2.79 (1.69 to 4.58; P Antihistamines are often used to treat the symptoms of allergies such as seasonal and perennial allergic rhinitis and urticaria.Due to the side effects of these medications, they are generally not recommended for routine, daily use.Since first-generation antihistamines can impair mental and motor functioning, they can impair a person’s ability to operate motor vehicles or heavy machinery. S., a person can be charged with a DUI (driving under the influence) if an automobile accident is deemed to be their fault while taking a first-generation antihistamine.Whom it may be suitable for: Can be ideal for the elderly because of fewer side effects when prescribed at lower doses.Pros: A very effective SSRI that can be easier to start and stay on than others.